| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
|---|
| Ligand | BDBM50123618 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1522030 (CHEMBL3627137) |
|---|
| IC50 | 138±n/a nM |
|---|
| Citation |  Yao, Y; Tu, Z; Liao, C; Wang, Z; Li, S; Yao, H; Li, Z; Jiang, S Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. J Med Chem58:7672-80 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyamine deacetylase HDAC10 |
|---|
| Name: | Polyamine deacetylase HDAC10 |
|---|
| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 71431.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q969S8 |
|---|
| Residue: | 669 |
|---|
| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
|
|
|
|---|
| BDBM50123618 |
|---|
| n/a |
|---|
| Name | BDBM50123618 |
|---|
| Synonyms: | CHEMBL3622727 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H34N4O5S2 |
|---|
| Mol. Mass. | 522.681 |
|---|
| SMILES | C\C=C1/NC(=O)c2csc(n2)[C@H](NC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
