| Reaction Details |
|---|
 | Report a problem with these data |
| Target | LIM domain kinase 1 |
|---|
| Ligand | BDBM50124353 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1520363 (CHEMBL3624101) |
|---|
| IC50 | 2000±n/a nM |
|---|
| Citation |  Charles, MD; Brookfield, JL; Ekwuru, TC; Stockley, M; Dunn, J; Riddick, M; Hammonds, T; Trivier, E; Greenland, G; Wong, AC; Cheasty, A; Boyd, S; Crighton, D; Olson, MF Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem58:8309-13 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| LIM domain kinase 1 |
|---|
| Name: | LIM domain kinase 1 |
|---|
| Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 72591.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_4505001 |
|---|
| Residue: | 647 |
|---|
| Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
|
|
|
|---|
| BDBM50124353 |
|---|
| n/a |
|---|
| Name | BDBM50124353 |
|---|
| Synonyms: | CHEMBL3623443 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18F3N3O2S |
|---|
| Mol. Mass. | 421.436 |
|---|
| SMILES | COc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
