Ki Summary

Reaction Details

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Target

Growth factor receptor-bound protein 7

Ligand

BDBM50124405

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1520388 (CHEMBL3624251)

77300±n/a nM

Citation

Watson, GM; Gunzburg, MJ; Ambaye, ND; Lucas, WA; Traore, DA; Kulkarni, K; Cergol, KM; Payne, RJ; Panjikar, S; Pero, SC; Perlmutter, P; Wilce, MC; Wilce, JA Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J Med Chem58:7707-18 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Growth factor receptor-bound protein 7

Name:

Growth factor receptor-bound protein 7

Synonyms:

B47 | Epidermal growth factor receptor GRB-7 | GRB7 | GRB7 adapter protein | GRB7_HUMAN

Type:

PROTEIN

Mol. Mass.:

59700.56

Organism:

Homo sapiens (Human)

Description:

ChEMBL_699661

Residue:

532

Sequence:

MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL

BDBM50124405

n/a

Name

BDBM50124405

Synonyms:

CHEMBL3623449

Type

Small organic molecule

Emp. Form.

C69H82N14O20S

Mol. Mass.

1459.536

SMILES

[H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(CC(O)=O)cc1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc3ccccc3[nH]1)NC(=O)CSC[C@H](NC2=O)C(N)=O)[C@@H](C)O |r|

Structure