| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50124405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520494 (CHEMBL3624733) |
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| Kd | 440000±n/a nM |
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| Citation |  Watson, GM; Gunzburg, MJ; Ambaye, ND; Lucas, WA; Traore, DA; Kulkarni, K; Cergol, KM; Payne, RJ; Panjikar, S; Pero, SC; Perlmutter, P; Wilce, MC; Wilce, JA Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J Med Chem58:7707-18 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50124405 |
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| n/a |
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| Name | BDBM50124405 |
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| Synonyms: | CHEMBL3623449 |
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| Type | Small organic molecule |
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| Emp. Form. | C69H82N14O20S |
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| Mol. Mass. | 1459.536 |
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| SMILES | [H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(CC(O)=O)cc1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc3ccccc3[nH]1)NC(=O)CSC[C@H](NC2=O)C(N)=O)[C@@H](C)O |r| |
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| Structure | 
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