| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SETD7 |
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| Ligand | BDBM50017721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1521883 (CHEMBL3626829) |
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| IC50 | 20000±n/a nM |
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| Citation |  Meng, F; Cheng, S; Ding, H; Liu, S; Liu, Y; Zhu, K; Chen, S; Lu, J; Xie, Y; Li, L; Liu, R; Shi, Z; Zhou, Y; Liu, YC; Zheng, M; Jiang, H; Lu, W; Liu, H; Luo, C Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem58:8166-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SETD7 |
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| Name: | Histone-lysine N-methyltransferase SETD7 |
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| Synonyms: | Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40691.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WTS6 |
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| Residue: | 366 |
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| Sequence: | MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
QATQQK
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| BDBM50017721 |
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| n/a |
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| Name | BDBM50017721 |
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| Synonyms: | 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine | 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine | 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine | 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine | 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine | 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene | CHEMBL516 | CYPROHEPTADINE |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N |
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| Mol. Mass. | 287.3981 |
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| SMILES | [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| |
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| Structure | 
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