Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50125582 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1519337 (CHEMBL3625049) |
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Ki | 5.5±n/a nM |
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Citation | Nocentini, A; Carta, F; Ceruso, M; Bartolucci, G; Supuran, CT Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. Bioorg Med Chem23:6955-66 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50125582 |
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n/a |
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Name | BDBM50125582 |
Synonyms: | CHEMBL3623665 |
Type | Small organic molecule |
Emp. Form. | C18H12ClN3O3 |
Mol. Mass. | 353.759 |
SMILES | Clc1cccc(c1)-n1cc(COc2ccc3ccc(=O)oc3c2)nn1 |
Structure |
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