Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor IX
LigandBDBM50125978
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1522950 (CHEMBL3630982)
Ki 3.7±n/a nM
Citation Zhang, TAndre, PBateman, TJChen, YHDesai, KEllsworth, KGeissler, WMGuo, LHruza, AJian, TMeng, DParker, DLQian, XReichert, PSherer, ECShu, MSmith, CJSonatore, LMTschirret-Guth, RNolting, AFOrr, RCampeau, LCAraki, KNishimura, TSakurada, IWood, HB Development of a novel class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:4945-9 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:P00740
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50125978
n/a
NameBDBM50125978
Synonyms:CHEMBL3627898 | US10189819, Example 77
TypeSmall organic molecule
Emp. Form.C26H21Cl2FN6O
Mol. Mass.523.389
SMILESCc1ncn(n1)-c1cc(Cl)c(C(=O)NC[C@@H](c2cccc(F)c2)c2cnc3[nH]c(C)cc3c2)c(Cl)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: