| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50061916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523466 (CHEMBL3630810) |
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| IC50 | 37±n/a nM |
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| Citation |  Dounay, AB; Tuttle, JB; Verhoest, PR Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem58:8762-82 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO | KMO_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55831.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487479 |
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| Residue: | 486 |
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| Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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| BDBM50061916 |
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| n/a |
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| Name | BDBM50061916 |
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| Synonyms: | 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide | CHEMBL134915 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O6S2 |
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| Mol. Mass. | 421.448 |
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| SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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