| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Ligand | BDBM50126149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523468 (CHEMBL3630812) |
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| IC50 | 13400±n/a nM |
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| Citation |  Dounay, AB; Tuttle, JB; Verhoest, PR Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem58:8762-82 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Synonyms: | AADAT_RAT | Aadat | Kat2 | Kynurenine/alpha-aminoadipate aminotransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47788.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_826599 |
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| Residue: | 425 |
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| Sequence: | MNYSRFLTATSLARKTSPIRATVEIMSRAPKDIISLAPGSPNPKVFPFKSAVFTVENGST
IRFEGEMFQRALQYSSSYGIPELLSWLKQLQIKLHNPPTVNYSPNEGQMDLCITSGCQDG
LCKVFEMLINPGDTVLVNEPLYSGALFAMKPLGCNFISVPSDDCGIIPEGLKKVLSQWKP
EDSKDPTKRTPKFLYTIPNGNNPTGNSLTGDRKKEIYELARKYDFLIIEDDPYYFLQFTK
PWEPTFLSMDVDGRVIRADSLSKVISSGLRVGFITGPKSLIQRIVLHTQISSLHPCTLSQ
LMISELLYQWGEEGFLAHVDRAIDFYKNQRDFILAAADKWLRGLAEWHVPKAGMFLWIKV
NGISDAKKLIEEKAIEREILLVPGNSFFVDNSAPSSFFRASFSQVTPAQMDLVFQRLAQL
IKDVS
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| BDBM50126149 |
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| n/a |
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| Name | BDBM50126149 |
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| Synonyms: | CHEMBL3629573 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16N2O3S |
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| Mol. Mass. | 376.428 |
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| SMILES | O=C1NC(=O)\C(S1)=C\c1cccc(c1)-c1ccc2CCN3c2c1CCC3=O |
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| Structure | 
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