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Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cystine/glutamate transporter | ||
| Ligand | BDBM50376126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1523603 (CHEMBL3631402) | ||
| IC50 | 200±n/a nM | ||
| Citation |  Larraufie, MH; Yang, WS; Jiang, E; Thomas, AG; Slusher, BS; Stockwell, BR Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. Bioorg Med Chem Lett25:4787-92 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cystine/glutamate transporter | |||
| Name: | Cystine/glutamate transporter | ||
| Synonyms: | SLC7A11 | XCT_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 55437.48 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_772170 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| BDBM50376126 | |||
| n/a | |||
| Name | BDBM50376126 | ||
| Synonyms: | ERASTIN | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H31ClN4O4 | ||
| Mol. Mass. | 547.045 | ||
| SMILES | CCOc1ccccc1-n1c(nc2ccccc2c1=O)C(C)N1CCN(CC1)C(=O)COc1ccc(Cl)cc1 |w:20.23,(-5.83,4.76,;-7.16,3.98,;-7.16,2.44,;-8.49,1.67,;-9.83,2.43,;-11.15,1.66,;-11.15,.11,;-9.82,-.66,;-8.48,.12,;-7.14,-.65,;-7.15,-2.2,;-5.83,-2.97,;-4.5,-2.2,;-3.17,-2.98,;-1.83,-2.21,;-1.83,-.67,;-3.16,.1,;-4.49,-.66,;-5.82,.11,;-5.82,1.65,;-8.49,-2.97,;-9.82,-2.19,;-8.5,-4.51,;-9.83,-5.27,;-9.84,-6.8,;-8.51,-7.58,;-7.17,-6.82,;-7.16,-5.27,;-8.53,-9.12,;-9.87,-9.88,;-7.2,-9.9,;-5.86,-9.14,;-4.53,-9.92,;-4.55,-11.46,;-3.22,-12.24,;-1.88,-11.48,;-.55,-12.26,;-1.88,-9.93,;-3.2,-9.16,)| | ||
| Structure | 
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