| Reaction Details |
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 | Report a problem with these data |
| Target | Proton-coupled folate transporter |
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| Ligand | BDBM50126173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523805 (CHEMBL3632256) |
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| IC50 | >1000±n/a nM |
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| Citation |  Wang, L; Wallace, A; Raghavan, S; Deis, SM; Wilson, MR; Yang, S; Polin, L; White, K; Kushner, J; Orr, S; George, C; O'Connor, C; Hou, Z; Mitchell-Ryan, S; Dann, CE; Matherly, LH; Gangjee, A 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem58:6938-59 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proton-coupled folate transporter |
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| Name: | Proton-coupled folate transporter |
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| Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49782.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469597 |
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| Residue: | 459 |
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| Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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| BDBM50126173 |
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| n/a |
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| Name | BDBM50126173 |
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| Synonyms: | CHEMBL3628345 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O6S |
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| Mol. Mass. | 447.465 |
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| SMILES | Nc1nc(N)c2c(CCCc3csc(c3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| |
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| Structure | 
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