Reaction Details |
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Target | Coagulation factor IX |
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Ligand | BDBM50126915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1524004 (CHEMBL3630476) |
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Ki | 2.6±n/a nM |
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Citation | Meng, D; Andre, P; Bateman, TJ; Berger, R; Chen, YH; Desai, K; Dewnani, S; Ellsworth, K; Feng, D; Geissler, WM; Guo, L; Hruza, A; Jian, T; Li, H; Metzger, J; Parker, DL; Reichert, P; Sherer, EC; Smith, CJ; Sonatore, LM; Tschirret-Guth, R; Wu, J; Xu, J; Zhang, T; Campeau, LC; Orr, R; Poirier, M; McCabe-Dunn, J; Araki, K; Nishimura, T; Sakurada, I; Hirabayashi, T; Wood, HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:5437-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor IX |
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Name: | Coagulation factor IX |
Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
Type: | Enzyme |
Mol. Mass.: | 51768.83 |
Organism: | Homo sapiens (Human) |
Description: | P00740 |
Residue: | 461 |
Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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BDBM50126915 |
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n/a |
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Name | BDBM50126915 |
Synonyms: | CHEMBL3629110 | US10351558, Example 138 |
Type | Small organic molecule |
Emp. Form. | C29H25ClN6O2 |
Mol. Mass. | 525.001 |
SMILES | Cc1ccc2n3C[C@@](CCc3c(C(N)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| |
Structure |
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