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TargetCoagulation factor IX
LigandBDBM50126916
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1524004
Ki 0.600000±n/a nM
Citation Meng DAndre PBateman TJBerger RChen YHDesai KDewnani SEllsworth KFeng DGeissler WMGuo LHruza AJian TLi HMetzger JParker DLReichert PSherer ECSmith CJSonatore LMTschirret-Guth RWu JXu JZhang TCampeau LCOrr RPoirier MMcCabe-Dunn JAraki KNishimura TSakurada IHirabayashi TWood HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett 25:5437-43 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50126916
n/a
NameBDBM50126916
Synonyms:CHEMBL3629111
TypeSmall organic molecule
Emp. Form.C29H24ClN5O3
Mol. Mass.525.986
SMILESCc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r|
Structure
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