| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50126916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1524005 (CHEMBL3630477) |
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| Ki | 234±n/a nM |
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| Citation |  Meng, D; Andre, P; Bateman, TJ; Berger, R; Chen, YH; Desai, K; Dewnani, S; Ellsworth, K; Feng, D; Geissler, WM; Guo, L; Hruza, A; Jian, T; Li, H; Metzger, J; Parker, DL; Reichert, P; Sherer, EC; Smith, CJ; Sonatore, LM; Tschirret-Guth, R; Wu, J; Xu, J; Zhang, T; Campeau, LC; Orr, R; Poirier, M; McCabe-Dunn, J; Araki, K; Nishimura, T; Sakurada, I; Hirabayashi, T; Wood, HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:5437-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50126916 |
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| n/a |
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| Name | BDBM50126916 |
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| Synonyms: | CHEMBL3629111 | US10351558, Example 139 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24ClN5O3 |
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| Mol. Mass. | 525.986 |
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| SMILES | Cc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| |
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| Structure | 
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