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TargetLactoylglutathione lyase
LigandBDBM50126960
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1524147 (CHEMBL3631232)
Ki 0.300000±n/a nM
Citation Sang, YShi, QMo, MNi, CLi, ZLiu, BDeng, QCreighton, DJZheng, ZB Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorg Med Chem Lett25:4724-7 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lactoylglutathione lyase
Name:Lactoylglutathione lyase
Synonyms:Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:Enzyme
Mol. Mass.:20772.95
Organism:Homo sapiens (Human)
Description:Q04760
Residue:184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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BDBM50126960
n/a
NameBDBM50126960
Synonyms:CHEMBL3629116
TypeSmall organic molecule
Emp. Form.C58H78Br2N14O26S2
Mol. Mass.1611.256
SMILESON(C(=O)SCC(NC(=O)CCC(NCCC(=O)OCCNC(=O)CCNC(=O)CC(=O)NCCNC(=O)CC(=O)NCCC(=O)NCCOC(=O)CCNC(CCC(=O)NC(CSC(=O)N(O)c1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O)C(O)=O)C(=O)NCC(O)=O)c1ccc(Br)cc1
Structure
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