Reaction Details |
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Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50126972 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1524156 (CHEMBL3631241) |
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IC50 | 13±n/a nM |
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Citation | Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Towards the evaluation in an animal disease model: Fluorinated 17ß-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme. Eur J Med Chem103:56-68 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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17-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
Type: | Oxidoreductase; single-pass type II membrane protein |
Mol. Mass.: | 42795.29 |
Organism: | Homo sapiens (Human) |
Description: | Enzyme was partially purified from human placenta. |
Residue: | 387 |
Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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BDBM50126972 |
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n/a |
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Name | BDBM50126972 |
Synonyms: | CHEMBL3629586 |
Type | Small organic molecule |
Emp. Form. | C24H14F5NO5S2 |
Mol. Mass. | 555.494 |
SMILES | Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F |
Structure |
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