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TargetMitogen-activated protein kinase 1
LigandBDBM50205363
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1524687 (CHEMBL3631081)
Kd 247000±n/a nM
Citation Burdick, DJ; Wang, S; Heise, C; Pan, B; Drummond, J; Yin, J; Goeser, L; Magnuson, S; Blaney, J; Moffat, J; Wang, W; Chen, H Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg Med Chem Lett25:4728-32 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM50205363
n/a
NameBDBM50205363
Synonyms:6-(benzylamino)purine | 6-BAP | 6-[(phenylmethyl)amino]-9H-purine | BAP | CHEMBL228862 | Cytokinin B | N(6)-(benzylamino)purine | N-benzyl-9H-purin-6-amine | N-benzyladenine | benzyladenine
TypeSmall organic molecule
Emp. Form.C12H11N5
Mol. Mass.225.2492
SMILESC(Nc1ncnc2nc[nH]c12)c1ccccc1
Structure
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