Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM50127094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1524688 (CHEMBL3631082) |
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IC50 | 37±n/a nM |
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Citation | Burdick, DJ; Wang, S; Heise, C; Pan, B; Drummond, J; Yin, J; Goeser, L; Magnuson, S; Blaney, J; Moffat, J; Wang, W; Chen, H Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg Med Chem Lett25:4728-32 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50127094 |
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n/a |
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Name | BDBM50127094 |
Synonyms: | CHEMBL3628383 |
Type | Small organic molecule |
Emp. Form. | C21H16N6 |
Mol. Mass. | 352.3919 |
SMILES | C(c1ccccc1)n1cc(cn1)-c1c[nH]c2ncc(nc12)-c1ccncc1 |
Structure |
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