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TargetTryptophan 2,3-dioxygenase
LigandBDBM50127137
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1524691 (CHEMBL3631085)
IC50 7380±n/a nM
Citation Wu, JSLin, SYLiao, FYHsiao, WCLee, LCPeng, YHHsieh, CLWu, MHSong, JSYueh, AChen, CHYeh, SHLiu, CYLin, SYYeh, TKHsu, JTShih, CUeng, SHHung, MSWu, SY Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening. J Med Chem58:7807-19 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 2,3-dioxygenase
Name:Tryptophan 2,3-dioxygenase
Synonyms:T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:PROTEIN
Mol. Mass.:47874.48
Organism:Homo sapiens (Human)
Description:ChEMBL_825691
Residue:406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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  Blast E-value cutoff:
BDBM50127137
n/a
NameBDBM50127137
Synonyms:CHEMBL3628552
TypeSmall organic molecule
Emp. Form.C17H10FN3O2
Mol. Mass.307.2786
SMILESFc1ccc(Cn2nnc3c2C(=O)c2ccccc2C3=O)cc1
Structure
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