| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Ligand | BDBM50127663 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1522501 (CHEMBL3631637) |
|---|
| Ki | 5000±n/a nM |
|---|
| Citation |  Deligia, F; Deiana, V; Gotti, C; Lazzari, P; Bottazzi, ME; Pucci, L; Fasoli, F; Ragusa, G; Pinna, GA; Murineddu, G Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora4ß2 neuronal nicotinic acetylcholine receptors. Eur J Med Chem103:429-37 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
|---|
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56502.44 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q05941 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
|
|
|
|---|
| BDBM50127663 |
|---|
| n/a |
|---|
| Name | BDBM50127663 |
|---|
| Synonyms: | CHEMBL3628504 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N4O2 |
|---|
| Mol. Mass. | 296.3238 |
|---|
| SMILES | [O-][N+](=O)c1ccc(cc1)-c1cncc(c1)N1CC2CC(C1)N2 |
|---|
| Structure | 
|
|---|
Search and Browse
