Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase 12
LigandBDBM50049400
Substrate/Competitorn/a
Meas. Tech.ChEBML_1523544
Temperature298.15±n/a K
Ki 33±n/a nM
Commentsextracted
Citation Karioti, ACeruso, MCarta, FBilia, ARSupuran, CT New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem23:7219-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50049400
n/a
NameBDBM50049400
Synonyms:(+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-taxifolin | (2R,3R)-2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one | (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one | 2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one | 3,5,7,3',4'-pentahydroxyflavanone | CHEMBL337309 | NSC-2801
TypeSmall organic molecule
Emp. Form.C15H12O7
Mol. Mass.304.2516
SMILESOC1C(=O)C(Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: