Reaction Details |
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Target | LIM domain kinase 1 |
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Ligand | BDBM50130039 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1524293 (CHEMBL3631886) |
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IC50 | 10.0±n/a nM |
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Citation | Cui, J; Ding, M; Deng, W; Yin, Y; Wang, Z; Zhou, H; Sun, G; Jiang, Y; Feng, Y Discovery of bis-aryl urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study. Bioorg Med Chem23:7464-77 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 1 |
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Name: | LIM domain kinase 1 |
Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72591.81 |
Organism: | Homo sapiens (Human) |
Description: | gi_4505001 |
Residue: | 647 |
Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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BDBM50130039 |
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n/a |
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Name | BDBM50130039 |
Synonyms: | CHEMBL3629276 |
Type | Small organic molecule |
Emp. Form. | C21H18FN5O2 |
Mol. Mass. | 391.3983 |
SMILES | COc1ccc(NC(=O)Nc2ccc(cc2F)-c2ncnc3[nH]cc(C)c23)cc1 |
Structure |
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