| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50101003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1525146 (CHEMBL3635484) |
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| IC50 | 1600±n/a nM |
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| Citation |  Gillis, EP; Eastman, KJ; Hill, MD; Donnelly, DJ; Meanwell, NA Applications of Fluorine in Medicinal Chemistry. J Med Chem58:8315-59 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50101003 |
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| n/a |
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| Name | BDBM50101003 |
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| Synonyms: | 3-((3-ethoxybenzyl)(3-phenoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol | 3-[(3-Ethoxy-benzyl)-(3-phenoxy-phenyl)-amino]-1,1,1-trifluoro-propan-2-ol | CHEMBL416623 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24F3NO3 |
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| Mol. Mass. | 431.4475 |
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| SMILES | CCOc1cccc(CN(CC(O)C(F)(F)F)c2cccc(Oc3ccccc3)c2)c1 |
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| Structure | 
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