| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50130314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1525161 (CHEMBL3635499) |
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| IC50 | 112±n/a nM |
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| Citation |  Gillis, EP; Eastman, KJ; Hill, MD; Donnelly, DJ; Meanwell, NA Applications of Fluorine in Medicinal Chemistry. J Med Chem58:8315-59 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50130314 |
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| n/a |
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| Name | BDBM50130314 |
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| Synonyms: | CHEMBL3633040 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F5N3O6S2 |
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| Mol. Mass. | 619.581 |
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| SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc(cc1OCCO)-c1ncccn1 |
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| Structure | 
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