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TargetVoltage-gated sodium channel alpha subunit Nav1.1
LigandBDBM50130524
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1525517
IC50 690±n/a nM
Citation Suzuki SKuroda TKimoto HDomon YKubota KKitano YYokoyama TShimizugawa ASugita RKoishi RAsano DTamaki KShinozuka TKobayashi H Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors. Bioorg Med Chem Lett 25:5419-23 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated sodium channel alpha subunit Nav1.1
Name:Voltage-gated sodium channel alpha subunit Nav1.1
Synonyms:Scn1a | Voltage-gated sodium channel alpha subunit Nav1.1
Type:PROTEIN
Mol. Mass.:25514.04
Organism:Mus musculus
Description:ChEMBL_109872
Residue:220
Sequence:
QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIM
ILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFD
FVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP
ALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFE
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  Blast E-value cutoff:
BDBM50130524
n/a
NameBDBM50130524
Synonyms:CHEMBL3634332
TypeSmall organic molecule
Emp. Form.C29H30N2O4
Mol. Mass.470.5595
SMILESOC(COc1cccc(c1)C(=O)c1ccccc1)CN1CCC(CC1)N1Cc2ccccc2C1=O
Structure
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