Reaction Details |
| Report a problem with these data |
Target | Kelch-like ECH-associated protein 1 |
---|
Ligand | BDBM50130557 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1525531 (CHEMBL3637038) |
---|
IC50 | 400±n/a nM |
---|
Citation | Jain, AD; Potteti, H; Richardson, BG; Kingsley, L; Luciano, JP; Ryuzoji, AF; Lee, H; Krunic, A; Mesecar, AD; Reddy, SP; Moore, TW Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem103:252-68 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Kelch-like ECH-associated protein 1 |
---|
Name: | Kelch-like ECH-associated protein 1 |
Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
Type: | PROTEIN |
Mol. Mass.: | 69664.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107924 |
Residue: | 624 |
Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
|
|
|
BDBM50130557 |
---|
n/a |
---|
Name | BDBM50130557 |
Synonyms: | CHEMBL3632882 |
Type | Small organic molecule |
Emp. Form. | C28H28N2O8S2 |
Mol. Mass. | 584.661 |
SMILES | CCOC(=O)CN(c1ccc(NS(=O)(=O)c2ccc(OC)cc2)c2ccccc12)S(=O)(=O)c1ccc(OC)cc1 |
Structure |
|