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TargetKelch-like ECH-associated protein 1
LigandBDBM50130557
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1525531 (CHEMBL3637038)
IC50 400±n/a nM
Citation Jain, ADPotteti, HRichardson, BGKingsley, LLuciano, JPRyuzoji, AFLee, HKrunic, AMesecar, ADReddy, SPMoore, TW Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem103:252-68 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kelch-like ECH-associated protein 1
Name:Kelch-like ECH-associated protein 1
Synonyms:Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19
Type:PROTEIN
Mol. Mass.:69664.53
Organism:Homo sapiens (Human)
Description:ChEMBL_107924
Residue:624
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50130557
n/a
NameBDBM50130557
Synonyms:CHEMBL3632882
TypeSmall organic molecule
Emp. Form.C28H28N2O8S2
Mol. Mass.584.661
SMILESCCOC(=O)CN(c1ccc(NS(=O)(=O)c2ccc(OC)cc2)c2ccccc12)S(=O)(=O)c1ccc(OC)cc1
Structure
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