| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM50130705 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1527068 (CHEMBL3637759) |
|---|
| Ki | 18±n/a nM |
|---|
| Citation |  Teo, T; Yang, Y; Yu, M; Basnet, SK; Gillam, T; Hou, J; Schmid, RM; Kumarasiri, M; Diab, S; Albrecht, H; Sykes, MJ; Wang, S An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis. Eur J Med Chem103:539-50 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51870.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBH9 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
|
|
|
|---|
| BDBM50130705 |
|---|
| n/a |
|---|
| Name | BDBM50130705 |
|---|
| Synonyms: | CHEMBL3632745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21FN4O2S |
|---|
| Mol. Mass. | 388.459 |
|---|
| SMILES | CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C |
|---|
| Structure | 
|
|---|
Search and Browse
