| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Ligand | BDBM50130841 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1525206 (CHEMBL3635517) |
|---|
| IC50 | 2.6±n/a nM |
|---|
| Citation |  Lingam, VS; Dahale, DH; Rathi, VE; Shingote, YB; Thakur, RR; Mindhe, AS; Kummari, S; Khairatkar-Joshi, N; Bajpai, M; Shah, DM; Sapalya, RS; Gullapalli, S; Gupta, PK; Gudi, GS; Jadhav, SB; Pattem, R; Thomas, A Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists. J Med Chem58:8292-308 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Synonyms: | PDE10_MOUSE | Pde10a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 89407.64 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1458264 |
|---|
| Residue: | 790 |
|---|
| Sequence: | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
|
|
|
|---|
| BDBM50130841 |
|---|
| n/a |
|---|
| Name | BDBM50130841 |
|---|
| Synonyms: | CHEMBL3634745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H19FN2O2 |
|---|
| Mol. Mass. | 422.4504 |
|---|
| SMILES | Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
