| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Ligand | BDBM50131822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1526222 (CHEMBL3636907) |
|---|
| IC50 | >6000±n/a nM |
|---|
| Citation |  Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. ACS Med Chem Lett6:961-5 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase Src |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 59838.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P12931 |
|---|
| Residue: | 536 |
|---|
| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
|---|
| BDBM50131822 |
|---|
| n/a |
|---|
| Name | BDBM50131822 |
|---|
| Synonyms: | CHEMBL3632719 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H25F3N6O |
|---|
| Mol. Mass. | 506.5222 |
|---|
| SMILES | Cn1c(Nc2cccc(c2)C(C)(C)C)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
