| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
|---|
| Ligand | BDBM50131825 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1526214 (CHEMBL3636899) |
|---|
| IC50 | 210±n/a nM |
|---|
| Citation |  Williams, TE; Subramanian, S; Verhagen, J; McBride, CM; Costales, A; Sung, L; Antonios-McCrea, W; McKenna, M; Louie, AK; Ramurthy, S; Levine, B; Shafer, CM; Machajewski, T; Renhowe, PA; Appleton, BA; Amiri, P; Chou, J; Stuart, D; Aardalen, K; Poon, D Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. ACS Med Chem Lett6:961-5 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase B-raf |
|---|
| Name: | Serine/threonine-protein kinase B-raf |
|---|
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 84446.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15056 |
|---|
| Residue: | 766 |
|---|
| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
|---|
| BDBM50131825 |
|---|
| n/a |
|---|
| Name | BDBM50131825 |
|---|
| Synonyms: | CHEMBL3632723 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H15F7N6O |
|---|
| Mol. Mass. | 536.4043 |
|---|
| SMILES | Cn1c(Nc2cc(ccc2F)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
