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TargetPlatelet-activating factor acetylhydrolase
LigandBDBM50132820
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1525084 (CHEMBL3635122)
IC50 11±n/a nM
Citation Chen, XXu, WWang, KMo, MZhang, WDu, LYuan, XXu, YWang, YShen, J Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors. J Med Chem58:8529-41 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Platelet-activating factor acetylhydrolase
Name:Platelet-activating factor acetylhydrolase
Synonyms:1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:PROTEIN
Mol. Mass.:50084.41
Organism:Homo sapiens (Human)
Description:ChEMBL_156212
Residue:441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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  Blast E-value cutoff:
BDBM50132820
n/a
NameBDBM50132820
Synonyms:CHEMBL3634556
TypeSmall organic molecule
Emp. Form.C24H14F5N5O2
Mol. Mass.499.3923
SMILESFc1cc(COc2ccn3c(cnc3n2)-c2cncnc2)cc(F)c1Oc1cccc(c1)C(F)(F)F
Structure
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