| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50133401 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1525819 (CHEMBL3635733) |
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| Ki | 51±n/a nM |
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| Citation |  La Regina, G; Coluccia, A; Famiglini, V; Pelliccia, S; Monti, L; Vullo, D; Nuti, E; Alterio, V; De Simone, G; Monti, SM; Pan, P; Parkkila, S; Supuran, CT; Rossello, A; Silvestri, R Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem58:8564-72 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50133401 |
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| n/a |
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| Name | BDBM50133401 |
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| Synonyms: | CHEMBL3632837 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19NO4S |
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| Mol. Mass. | 381.445 |
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| SMILES | COC(=O)c1ccc(Cc2ccc(cc2)-c2ccc(cc2)S(N)(=O)=O)cc1 |
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| Structure | 
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