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TargetCytochrome P450 2C8
LigandBDBM50133595
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1526170 (CHEMBL3636695)
IC50>100000±n/a nM
Citation Ruggeri, RBBuckbinder, LBagley, SWCarpino, PAConn, ELDowling, MSFernando, DPJiao, WKung, DWOrr, STQi, YRocke, BNSmith, AWarmus, JSZhang, YBowles, DWidlicka, DWEng, HRyder, TSharma, RWolford, AOkerberg, CWalters, KMaurer, TSZhang, YBonin, PDSpath, SNXing, GHepworth, DAhn, KKalgutkar, AS Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem58:8513-28 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2C8
Name:Cytochrome P450 2C8
Synonyms:CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:Protein
Mol. Mass.:55839.23
Organism:Homo sapiens (Human)
Description:P10632
Residue:490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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  Blast E-value cutoff:
BDBM50133595
n/a
NameBDBM50133595
Synonyms:CHEMBL3633460
TypeSmall organic molecule
Emp. Form.C13H12ClN3O3S
Mol. Mass.325.771
SMILESCOc1ccc(Cl)cc1-c1cc(=O)[nH]c(=S)n1CC(N)=O
Structure
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