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TargetMyeloperoxidase
LigandBDBM50133600
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1526125 (CHEMBL3636509)
Ki 501±n/a nM
Citation Ruggeri, RBBuckbinder, LBagley, SWCarpino, PAConn, ELDowling, MSFernando, DPJiao, WKung, DWOrr, STQi, YRocke, BNSmith, AWarmus, JSZhang, YBowles, DWidlicka, DWEng, HRyder, TSharma, RWolford, AOkerberg, CWalters, KMaurer, TSZhang, YBonin, PDSpath, SNXing, GHepworth, DAhn, KKalgutkar, AS Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem58:8513-28 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Myeloperoxidase
Name:Myeloperoxidase
Synonyms:84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN
Type:Enzyme
Mol. Mass.:83888.32
Organism:Homo sapiens (Human)
Description:P05164
Residue:745
Sequence:
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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  Blast E-value cutoff:
BDBM50133600
n/a
NameBDBM50133600
Synonyms:CHEMBL3633457
TypeSmall organic molecule
Emp. Form.C17H22N2O4S
Mol. Mass.350.433
SMILESCOc1ccc(c(OC)c1)-c1cc(=O)[nH]c(=S)n1CCOC(C)C
Structure
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