| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM50133875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1526534 (CHEMBL3635422) |
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| Ki | 660±n/a nM |
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| Citation |  Behnke, D; Cotesta, S; Hintermann, S; Fendt, M; Gee, CE; Jacobson, LH; Laue, G; Meyer, A; Wagner, T; Badiger, S; Chaudhari, V; Chebrolu, M; Pandit, C; Hoyer, D; Betschart, C Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorg Med Chem Lett25:5555-60 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM50133875 |
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| n/a |
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| Name | BDBM50133875 |
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| Synonyms: | CHEMBL3634023 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20F3N5O2 |
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| Mol. Mass. | 455.4324 |
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| SMILES | C[C@H](NC(=O)COc1cc(c2c(nn(C)c2n1)-c1ccccn1)C(F)(F)F)c1ccccc1 |r| |
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| Structure | 
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