Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM123357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1526535 (CHEMBL3635423) |
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Ki | 5.0±n/a nM |
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Citation | Behnke, D; Cotesta, S; Hintermann, S; Fendt, M; Gee, CE; Jacobson, LH; Laue, G; Meyer, A; Wagner, T; Badiger, S; Chaudhari, V; Chebrolu, M; Pandit, C; Hoyer, D; Betschart, C Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorg Med Chem Lett25:5555-60 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM123357 |
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n/a |
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Name | BDBM123357 |
Synonyms: | US8742106, 4.7 |
Type | Small organic molecule |
Emp. Form. | C23H24N6O2 |
Mol. Mass. | 416.4757 |
SMILES | C[C@H](NC(=O)COc1cc(C)c2c(nn(C)c2n1)-c1ncccn1)c1ccc(C)cc1 |r| |
Structure |
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