Reaction Details |
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Target | Mitogen-activated protein kinase 7 |
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Ligand | BDBM50134187 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1539778 |
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IC50 | 220±n/a nM |
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Citation | Furlotti, G; Alisi, MA; Cazzolla, N; Dragone, P; Durando, L; Magarņ, G; Mancini, F; Mangano, G; Ombrato, R; Vitiello, M; Armirotti, A; Capurro, V; Lanfranco, M; Ottonello, G; Summa, M; Reggiani, A Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders. J Med Chem58:8920-37 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 7 |
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Name: | Mitogen-activated protein kinase 7 |
Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 |
Type: | Protein |
Mol. Mass.: | 88377.36 |
Organism: | Homo sapiens (Human) |
Description: | Q13164 |
Residue: | 816 |
Sequence: | MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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BDBM50134187 |
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n/a |
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Name | BDBM50134187 |
Synonyms: | CHEMBL3735506 | US11472795, Example C | US9611249, Compound 8 |
Type | Small organic molecule |
Emp. Form. | C23H26F2N4O2 |
Mol. Mass. | 428.4749 |
SMILES | COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1 |
Structure |
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