| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50134211 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1542247 (CHEMBL3745469) |
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| IC50 | 2.7±n/a nM |
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| Citation |  Gray, WT; Frey, KM; Laskey, SB; Mislak, AC; Spasov, KA; Lee, WG; Bollini, M; Siliciano, RF; Jorgensen, WL; Anderson, KS Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. ACS Med Chem Lett6:1075-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50134211 |
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| n/a |
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| Name | BDBM50134211 |
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| Synonyms: | CHEMBL1923492 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15F2N3O4 |
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| Mol. Mass. | 411.3583 |
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| SMILES | Fc1ccc(Oc2cc(F)cc(\C=C\C#N)c2)c(OCCn2ccc(=O)[nH]c2=O)c1 |
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| Structure | 
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