Reaction Details |
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Target | Carbonic anhydrase, alpha family |
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Ligand | BDBM10874 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1543854 (CHEMBL3749744) |
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Ki | 41±n/a nM |
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Citation | Vullo, D; Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorg Med Chem Lett26:401-5 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase, alpha family |
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Name: | Carbonic anhydrase, alpha family |
Synonyms: | Carbonic anhydrase, alpha family |
Type: | PROTEIN |
Mol. Mass.: | 35831.01 |
Organism: | Thiomicrospira crunogena (strain XCL-2) |
Description: | ChEMBL_109899 |
Residue: | 315 |
Sequence: | MKKRFSFIFIFLVALPLYSANNVAAPLIDLGAEAKKQAQKSAATQSAVPEKESATKVAEK
QKEPEEKAKPEPKKPPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTS
LPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYP
MEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPA
DKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLK
SWPDRNRANTVYEFY
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BDBM10874 |
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n/a |
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Name | BDBM10874 |
Synonyms: | 6-hydroxy-1,3-benzothiazole-2-sulfonamide | CHEMBL6685 | aromatic/heteroaromatic sulfonamide 19 |
Type | Small organic molecule |
Emp. Form. | C7H6N2O3S2 |
Mol. Mass. | 230.264 |
SMILES | NS(=O)(=O)c1nc2ccc(O)cc2s1 |
Structure |
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