| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 3 |
|---|
| Ligand | BDBM50134590 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1544298 (CHEMBL3751415) |
|---|
| IC50 | 30±n/a nM |
|---|
| Citation |  Adams, M; Kobayashi, T; Lawson, JD; Saitoh, M; Shimokawa, K; Bigi, SV; Hixon, MS; Smith, CR; Tatamiya, T; Goto, M; Russo, J; Grimshaw, CE; Swann, S Fragment-based drug discovery of potent and selective MKK3/6 inhibitors. Bioorg Med Chem Lett26:1086-9 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 3 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 3 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39321.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 347 |
|---|
| Sequence: | MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
|
|
|
|---|
| BDBM50134590 |
|---|
| n/a |
|---|
| Name | BDBM50134590 |
|---|
| Synonyms: | CHEMBL3747443 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H10N4O |
|---|
| Mol. Mass. | 214.2233 |
|---|
| SMILES | NC(=O)c1nc(ccc1N)-c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
