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TargetMitogen-activated protein kinase 8
LigandBDBM50134602
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1544314 (CHEMBL3751431)
IC50 910±n/a nM
Citation Simon-Szabó, LKokas, MGreff, ZBoros, SBánhegyi, PZsákai, LSzántai-Kis, CVantus, TMandl, JBánhegyi, GVályi-Nagy, IOrfi, LUllrich, ACsala, MKéri, G Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes. Bioorg Med Chem Lett26:424-8 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 8
Name:Mitogen-activated protein kinase 8
Synonyms:JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:Enzyme
Mol. Mass.:48297.57
Organism:Homo sapiens (Human)
Description:JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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  Blast E-value cutoff:
BDBM50134602
n/a
NameBDBM50134602
Synonyms:CHEMBL3747489
TypeSmall organic molecule
Emp. Form.C19H20F2N6O4S
Mol. Mass.466.462
SMILESCn1c2nc(NC3CCN(CC3)S(N)(=O)=O)ncc2cc(Oc2ccc(F)cc2F)c1=O
Structure
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