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TargetMisshapen-like kinase 1
LigandBDBM50134771
Substrate/Competitorn/a
Meas. Tech.ChEBML_1549428
IC50 8.0±n/a nM
Citation Ammirati MBagley SWBhattacharya SKBuckbinder LCarlo AAConrad RCortes CDow RLDowling MSEl-Kattan AFord KGuimar„es CRHepworth DJiao WLaPerle JLiu SLondregan ALoria PMMathiowetz AMMunchhof MOrr STPetersen DNPrice DASkoura ASmith ACWang J Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett 6:1128-33 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Misshapen-like kinase 1
Name:Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1
Synonyms:GCK family kinase MiNK | MAPK/ERK kinase kinase kinase 6 | MEK kinase kinase 6 | MEKKK 6 | Misshapen/NIK-related kinase | Mitogen-activated protein kinase kinase kinase kinase 6
Type:PROTEIN
Mol. Mass.:149838.92
Organism:Homo sapiens (Human)
Description:ChEMBL_793919
Residue:1332
Sequence:
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
FMTLNRNCIMNW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50134771
n/a
NameBDBM50134771
Synonyms:CHEMBL3754515
TypeSmall organic molecule
Emp. Form.C16H13ClN4
Mol. Mass.296.754
SMILESNc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1
Structure
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