| Reaction Details |
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 | Report a problem with these data |
| Target | Misshapen-like kinase 1 |
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| Ligand | BDBM50134771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1549428 |
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| IC50 | 8.0±n/a nM |
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| Citation |  Ammirati M; Bagley SW; Bhattacharya SK; Buckbinder L; Carlo AA; Conrad R; Cortes C; Dow RL; Dowling MS; El-Kattan A; Ford K; Guimarães CR; Hepworth D; Jiao W; LaPerle J; Liu S; Londregan A; Loria PM; Mathiowetz AM; Munchhof M; Orr ST; Petersen DN; Price DA; Skoura A; Smith AC; Wang J Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett 6:1128-33 (2015) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Misshapen-like kinase 1 |
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| Name: | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
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| Synonyms: | GCK family kinase MiNK | MAPK/ERK kinase kinase kinase 6 | MEK kinase kinase 6 | MEKKK 6 | Misshapen/NIK-related kinase | Mitogen-activated protein kinase kinase kinase kinase 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 149838.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_793919 |
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| Residue: | 1332 |
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| Sequence: | MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
FMTLNRNCIMNW
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| BDBM50134771 |
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| n/a |
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| Name | BDBM50134771 |
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| Synonyms: | CHEMBL3754515 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClN4 |
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| Mol. Mass. | 296.754 |
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| SMILES | Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1 |
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| Structure | 
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