| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50134784 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1539069 (CHEMBL3738285) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Chao, B; Li, BX; Xiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm6:510-520 (2015) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50134784 |
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| n/a |
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| Name | BDBM50134784 |
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| Synonyms: | CHEMBL526243 | TCMDC-137820 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N6 |
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| Mol. Mass. | 314.344 |
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| SMILES | Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1 |
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| Structure | 
|
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