| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50135185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1545479 (CHEMBL3748723) |
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| Ki | 0.040000±n/a nM |
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| Citation |  Flores, A; Massarelli, I; Thoden, JB; Plum, LA; DeLuca, HF A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1a,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo. J Med Chem58:9731-41 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47811.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1505946 |
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| Residue: | 423 |
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| Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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| BDBM50135185 |
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| n/a |
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| Name | BDBM50135185 |
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| Synonyms: | CHEMBL3746759 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H42F2O3 |
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| Mol. Mass. | 452.6174 |
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| SMILES | [H][C@@]1([#6]-[#6][C@@]2([H])\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)[#6@H](-[#6])-[#6]-[#6]C(F)(F)C([#6])([#6])[#8] |r| |
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| Structure | 
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