Reaction Details |
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Target | Serine protease hepsin |
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Ligand | BDBM50135268 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1544367 (CHEMBL3748443) |
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Ki | 1.0±n/a nM |
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Citation | Kwon, H; Kim, Y; Park, K; Choi, SA; Son, SH; Byun, Y Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors. Bioorg Med Chem Lett26:310-4 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine protease hepsin |
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Name: | Serine protease hepsin |
Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
Type: | Enzyme |
Mol. Mass.: | 45016.98 |
Organism: | Homo sapiens (Human) |
Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
Residue: | 417 |
Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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BDBM50135268 |
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n/a |
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Name | BDBM50135268 |
Synonyms: | CHEMBL3747482 |
Type | Small organic molecule |
Emp. Form. | C22H36N8O5S |
Mol. Mass. | 524.637 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1 |r| |
Structure |
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