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TargetSerine protease hepsin
LigandBDBM50135276
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1544367 (CHEMBL3748443)
Ki>10000±n/a nM
Citation Kwon, HKim, YPark, KChoi, SASon, SHByun, Y Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors. Bioorg Med Chem Lett26:310-4 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine protease hepsin
Name:Serine protease hepsin
Synonyms:HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1
Type:Enzyme
Mol. Mass.:45016.98
Organism:Homo sapiens (Human)
Description:Human deglycosylated hepsin was expressed in Pichia pastoris.
Residue:417
Sequence:
MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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  Blast E-value cutoff:
BDBM50135276
n/a
NameBDBM50135276
Synonyms:CHEMBL3746062
TypeSmall organic molecule
Emp. Form.C20H31N5O3
Mol. Mass.389.4918
SMILESCC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1ccccc1 |r|
Structure
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