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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50136452
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1548095 (CHEMBL3757927)
EC50 4.1±n/a nM
Citation Horan, JCKuzmich, DLiu, PDiSalvo, DLord, JMao, CHopkins, TDYu, HHarcken, CBetageri, RHill-Drzewi, MPatenaude, LPatel, MFletcher, KTerenzzio, DLinehan, BXia, HPatel, MStudwell, DMiller, CHickey, ELevin, JISmith, DKemper, RAModis, LKBannen, LCChan, DSMac, MBNg, SWang, YXu, WLemieux, RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett26:466-71 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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  Blast E-value cutoff:
BDBM50136452
n/a
NameBDBM50136452
Synonyms:CHEMBL3752984
TypeSmall organic molecule
Emp. Form.C24H27ClFN5O4
Mol. Mass.503.954
SMILESCC(C)Nc1cc(cc(C)n1)-c1nc(no1)-c1cc(F)c(OC[C@H]2COCCN2C(C)=O)cc1Cl |r|
Structure
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