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TargetSphingosine 1-phosphate receptor 3
LigandBDBM50136557
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1548096 (CHEMBL3757928)
EC50>10000±n/a nM
Citation Horan, JCKuzmich, DLiu, PDiSalvo, DLord, JMao, CHopkins, TDYu, HHarcken, CBetageri, RHill-Drzewi, MPatenaude, LPatel, MFletcher, KTerenzzio, DLinehan, BXia, HPatel, MStudwell, DMiller, CHickey, ELevin, JISmith, DKemper, RAModis, LKBannen, LCChan, DSMac, MBNg, SWang, YXu, WLemieux, RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett26:466-71 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 3
Name:Sphingosine 1-phosphate receptor 3
Synonyms:C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42278.13
Organism:Homo sapiens (Human)
Description:Q99500
Residue:378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50136557
n/a
NameBDBM50136557
Synonyms:CHEMBL3754035
TypeSmall organic molecule
Emp. Form.C20H20Cl2FN3O4
Mol. Mass.456.295
SMILESCC(C)Oc1ccc(cc1Cl)-c1nc(no1)-c1cc(F)c(OC[C@H](N)CO)cc1Cl |r|
Structure
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