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TargetSphingosine 1-phosphate receptor 3
LigandBDBM50136553
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1548096
EC50>10000±n/a nM
Citation Horan JCKuzmich DLiu PDiSalvo DLord JMao CHopkins TDYu HHarcken CBetageri RHill-Drzewi MPatenaude LPatel MFletcher KTerenzzio DLinehan BXia HPatel MStudwell DMiller CHickey ELevin JISmith DKemper RAModis LKBannen LCChan DSMac MBNg SWang YXu WLemieux RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett 26:466-71 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 3
Name:Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3
Synonyms:EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42278.13
Organism:Homo sapiens (Human)
Description:Q99500
Residue:378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50136553
n/a
NameBDBM50136553
Synonyms:CHEMBL3753479
TypeSmall organic molecule
Emp. Form.C22H24FN5O3
Mol. Mass.425.4561
SMILESCC(C)Cc1cc(nc(C)n1)-c1nc(no1)-c1ccc(O[C@@H]2CCC(=O)NC2)c(F)c1 |r|
Structure
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