| Reaction Details |
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 | Report a problem with these data |
| Target | Perforin-1 |
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| Ligand | BDBM50137379 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1549002 (CHEMBL3756437) |
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| IC50 | 670±n/a nM |
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| Citation |  Miller, CK; Huttunen, KM; Denny, WA; Jaiswal, JK; Ciccone, A; Browne, KA; Trapani, JA; Spicer, JA Diarylthiophenes as inhibitors of the pore-forming protein perforin. Bioorg Med Chem Lett26:355-60 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Perforin-1 |
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| Name: | Perforin-1 |
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| Synonyms: | PERF_HUMAN | PFP | PRF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61392.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1285138 |
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| Residue: | 555 |
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| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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| BDBM50137379 |
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| n/a |
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| Name | BDBM50137379 |
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| Synonyms: | CHEMBL3754407 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13NO4S |
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| Mol. Mass. | 351.376 |
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| SMILES | NC(=O)c1ccc(cc1O)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 |
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| Structure | 
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